Board Thread:General Wiki Discussion/@comment-26267590-20170120173057/@comment-31532017-20170121003922

Diexilius wrote: Have you heard of heterochromia iridum? It's a mutation that a small part of the population has. If you have complete heterochromia your eyes are two different colours. I'm pretty sure I never read something like it in any story. Funny thing is, I'm actually making a pasta with the main character having heterochromia iridum. Actually there are a few stories out there that do include it.

As for OP; I think it depends heavily onto the situation and how the writer/author uses it.