User blog comment:Raidra/Diseases/@comment-27838637-20170413153028

I think a big one missing from most of the 'horrible disease' lists I have read is Nectrotizing Faciitis.

It's pretty much a disease that essentially causes bacteria to destroy your flesh. This infection spreads quickly, meaning there are some pretty greusome cases of this, and most infected limbs have to be amputated due to the sheer extent of tissue damage.