User blog comment:Necrosanity/The Ultimate Conundrum Cracker/@comment-4099220-20130513001824

In this case; what has been, is. What is, will be. Simple as that.

Fundamentally; we're nothing but atoms anyway, thus making this issue not worthwhile.

However, to answer your question, male/female is determined by the XX/XY chromosomes and (on a visible level) the genetalia. Whatever package said person is carrying is determined by these chromosomes. Thus, if it has or had (note "had". I've seen weirder shit) the corresponding chromsomes and genetalia, it is that gender.