User blog comment:CrazyWords/Poll on Writing Ideas/@comment-24101790-20150503052845

I would lean away from personalities as it seems to share some similarity to a character arc in Paranoia Agent

Cancer seems like it could be interesting if you try to mix horror and feels (they go together like chocolate and peanut butter) as opposed to trying to go with a straight-up horror approach. So that has my vote on the condition that you take it to the Writer's Workshop first for feedback.